The Minutemen can become hostile with the Railroad if they don't sound the evacuation signal during The Nuclear Option.If the Sole Survivor wishes to end the main quest by siding with the Minutemen, the Institute is the only faction that needs to be destroyed or even made hostile. The Minutemen route only becomes available if the Sole Survivor becomes hostile with the Institute, either by attacking them or by getting into a heated argument with Father.Siding with the Institute might make the Minutemen hostile, but this can easily be avoided by selecting the appropriate dialogue and passing several dialogue checks.Progressing through one's questline will eventually make the other factions hostile to the Sole Survivor. The Brotherhood of Steel, the Institute, and the Railroad are mutually hostile.Nuka-nuke launcher or Nuka-World jumpsuit World of Refreshment, Fizztop Mountain, The Parlor, Bradberton AmphitheaterДў of the following gang perks Ace Operator perk, Chosen Disciple perk, or Pack Alpha perk The Minutemen quest line begins when the Sole Survivor meets Preston Garvey in Concord, and interacts closely with the settlement building system throughout. Underground Undercover ( the Railroad branch) - Given by Desdemona if the player character joined the Railroad by completing the Tradecraft quest, or was already given if they used the Railroad to advance in the Molecular Level.Inside Job ( the Minutemen branch) - Given by Sturges if the player character completed Old Guns, or was already given if they used the Minutemen to advance in the Molecular Level.From Within ( Brotherhood of Steel branch) - Given by Elder Maxson if the player character completed Show No Mercy, or was already given if they used the Brotherhood of Steel to advance in the Molecular Level.Synth Retention ( the Institute branch) - Starts automatically.The following quests become available after completing Institutionalized:

However, should the Sole Survivor join and support the Institute, the main quest ends with the Nuclear Family quest.

Should the player character decide to oppose the Institute by supporting any of the other three factions, the main quest ends with The Nuclear Option quest (there are actually three variants of the same quest, one for each faction opposing the Institute). In some situations, this can be delayed (or even accelerated) with certain actions or certain dialogue choices. Certain events in those factions' quests can make other factions hostile to the Sole Survivor, thus locking them from those branches and failing all of that faction's on-going quests. At this point, the main quest's structure splits into four different branches, one for each of the four main factions. Synths throughout the Commonwealth become friendly (optional)ДЄct three begins when the Sole Survivor acquires the ability to fast-travel to and from the Institute at the end of Institutionalized.

The main story begins on Octowithin the Sole Survivor's pre-War home in Sanctuary Hills, just minutes before the Great War.ДЄct one begins when the Sole Survivor awakens in the year 2287, approximately 210 years after entering their cryo pod in Vault 111. This, combined with the endless number of radiant quests and the lack of any level cap, significantly extends the potential length of playing the game.ДЄs listed below, there are 191 quests in the base game, with a total of 272 with all add-ons installed. Instead, it continues with new post-story content, while the outcomes of the main quests have a visible impact on the world. The game does not end after the finale of act three. The add-ons include their own selection of main, side, miscellaneous and radiant quests which can be completed at almost any point during or after the main storyline, and which can even interact with the main quests in some ways. These radiant quests use randomized characters, locations and other elements and often can be repeated infinitely.

The game also includes a 'radiant quest system'. In addition to the usual main quest line, side and miscellaneous quests have been added. Fallout 4 features an expanded quest system, compared to that of previous Fallout games.

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